CLINICAL AND IMMUNOLOGICAL FEATURES OF NON-SPECIFIC ULCERATIVE COLITIS

Abstract

To study the clinical and immunological features of nonspecific ulcerative colitis. The absolute and relative composition of T- and B-lymphocytes, the concentration of immunoglobulins of classes A, M, G, the number and functional activity of natural killers in 48 patients diagnosed with ulcerative colitis were studied.
Decrease in relative number of T-lymphocytes, increase in relative and absolute number of B-lymphocytes, concentration of class A, M, G immunoglobulins, number and functional activity of natural killers were found. It has been confirmed that the state of the immune system in patients with UC directly depends on the form of the disease, the severity of the disease and the activity of the pathological process.
Our results confirm that the determination of the state of the immune system in UC can serve as a criterion for determining the form and severity of UC.